Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation
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منابع مشابه
Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation.
The Scientific Committee of Molecular Biology Techniques (C-MBT) in Clinical Chemistry of the IFCC has initiated a joint project in co-operation with the European Commission, Joint Research Centre, Institute of Reference Materials and Measurements to develop and produce plasmid-type reference materials (RMs) for the analysis of the human prothrombin gene G20210A mutation. Although DNA tests hav...
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Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
متن کاملProthrombin gene mutation (G20210A) in healthy Centenarians.
A recently described genetic variant of the prothrombin gene (G to A transition at nucleotide position 20210) is associated with an increased risk of venous thrombosis (1). The 20210A prothrombin allele may precipitate cerebral ischemia or myocardial infarction in young patients with known prothrombotic abnormalities (2, 3). Similarly, it has been demonstrated that factor V Leiden further incre...
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References 1. Sunderman FW. The clinical biochemistry of 59-nucleotidase [Review]. Ann Clin Lab Sci 1990;20:123–39. 2. Bodansky O, Schwartz MK. 59-Nucleotidase [Review]. Adv Clin Chem 1968; 11:277–328. 3. Dixon TF, Purdom M. Serum 59-nucleotidase. J Clin Pathol 1954;7:341–3. 4. Eshchar J, Rudzki C, Zimmerman HJ. Serum levels of 59-nucleotidase in disease. Am J Clin Pathol 1967;47:598–606. 5. Be...
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We have investigated the prevalence of the Factor II G20210A and Factor V G1691A single nucleotide polymorphisms (SNPs) in a South Indian-Tamil Nadu population. The SNP genotyping was performed using a polymerase chain reaction (PCR)/restriction fragment length polymorphism analysis and by a recently FDA-approved LightCycler real-time PCR assay. Of 72 samples that were genotyped, 4 (5.5%) patie...
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ژورنال
عنوان ژورنال: Clinical Chemistry and Laboratory Medicine (CCLM)
سال: 2005
ISSN: 1434-6621,1437-4331
DOI: 10.1515/cclm.2005.145